Does Testosterone Affect Your Hair?
Does Testosterone Affect Your Hair?
Testosterone is a hormone belonging to the group of androgens, it is produced mainly in the testes, although the adrenal glands secrete small amounts of it as well. Testosterone is a male sex hormone and an anabolic steroid. In men, testosterone allows the correct development of the male genitalia, as well as the development of secondary sexual characteristics, such as the increase of muscle tissue.
On average, the concentration of testosterone in the blood plasma in a male human adult is ten times higher than the concentration in the plasma of female human adults, but as the metabolic consumption of testosterone in men is higher, the production daily is approximately 20 times higher in men. On the other hand, women are more sensitive to the hormone.
Testosterone fulfills important functions in the body, however, the problem arises when testosterone is converted to Dihydrotestosterone (DHT), which has harmful effects on the scalp and hair follicle according to Michigan Hair Transplant Specialists.
Dihydrotestosterone (DHT) is an active biological metabolite of the hormone testosterone, synthesized mainly in the prostate, in the testes, in the hair follicles and the adrenal glands by the enzyme 5α-reductase.
The enzyme Glucuronide 3α-androstanediol is responsible for metabolizing unused DHT so that the liver can break down this androgen and eliminate it from your body, preventing an excess of this hormone.
In cases of androgenic alopecia, it has become clear that both sexes have an enzyme imbalance. Most people suffering from androgenic alopecia have an excess of 5a-reductase that converts testosterone to DHT.
Testosterone circulates throughout the body in the bloodstream. Quickly, blood circulation transports testosterone to the hair follicle. When testosterone reacts with 5a-reductase in the sebaceous glands, DHT is formed. Because the body has a tendency to store DHT in the skin and specifically in the scalp, the androgenic receptors around the hair follicle are especially sensitive to the collection and storage of DHT note Michigan hair transplant specialists.
DHT acts on the androgen receptors that surround the follicle, causing inflammation of the follicle that will become more visible as hair loss accelerates. Obviously, an inflamed hair follicle generates unnecessary pressure on hair growth. The inflammation around the follicle also restricts the flow of blood to the area. This not only means that the hair growth proteins will not reach the follicle, but that the antiandrogen enzymes will not be able to metabolize DHT.
DHT also accelerates the metabolism of the follicle, shortens the growth phase of the hair, so that the new hair does not reach the size or thickness of its predecessors.
How to decrease DHT?
1.- Reduction of DHT by increasing the testosterone-binding proteins
Only free testosterone can be metabolized in DHT, this means that if free testosterone binds to certain proteins we decrease the formation of DHT.
Sex hormone binding globulin (SHBG) is a protein that binds to free testosterone and transports it through the blood. There are many foods, supplements, and medications that help increase SHBG (and decrease free testosterone) Like S-equol which is an abundant isoflavone in soy. Isoflavones can increase the production of SHBG in the liver and bind to biologically active testosterone. This results in the decrease of free testosterone. This study compares blood testosterone levels with androgenic alopecia abundance.
2.- Competitive inhibition of 5-alpha-reductase
5-alpha reductase needs a coenzyme known as nicotinamide adenine dinucleotide phosphate (NADPH) to initiate the process of DHT conversion. An effective way to stop the formation of 5-alpha-reductase.
(and reduce DHT) is to competitively inhibit NADPH or block NADPH.
Some research shows that Finasteride and Dutasteride compete with NADPH. The molecules of Finasteride and Dutasteride take the place of NADPH in a cell, and in the absence of NADPH, 5-alpha-reductase cannot be formed.
Finasteride can bind to NADPH and change the structure of NADPH, preventing the formation of 5-alpha reductase. The end result: free testosterone can no longer be converted to DHT and this lowers the chances of having to undergo Hair Transplants Michigan.
3.- Steroid androgen receptor blockers
When it comes to hair loss (and the reduction of DHT), the most popular androgen receptor blocker seems to be spironolactone. This is a blocker of androgen receptors derived from the hormone progesterone.
Spironolactone reduces DHT by blocking androgen receptors, and doctors often prescribe an oral form for androgenic alopecia. Spironolactone is a powerful antiandrogen and has a wide feminizing capacity. In men, it is recommended to use topical form so that we can concentrate its anti-androgenic effects on the scalp and minimize the risk of feminization.
4.- Increase of DHT Metabolizing Enzymes
3α-HSD is one of the enzymes that metabolize DHT in different subproducts. We can increase the activity of 3α-HSD and, therefore, decrease DHT levels if we consume foods containing sulforaphane to improve hair health, such as broccoli.
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